Amine Functionalization of Cholecyst-Derived Extracellular Matrix with Generation 1 PAMAM Dendrimer
نویسندگان
چکیده
منابع مشابه
Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer.
A method to functionalize cholecyst-derived extracellular matrix (CEM) with free amine groups was established in an attempt to improve its potential for tethering of bioactive molecules. CEM was incorporated with Generation-1 polyamidoamine (G1 PAMAM) dendrimer by using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide and N-hydroxysuccinimide cross-linking system. The nature of incorporation of P...
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The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 ratio via a diethylene glycol linker. A lauroyl chain (L), a lipophilic permeability enhancer, was attached to G3 and G0 prodrugs. The G3 and G0 conju...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2008
ISSN: 1525-7797,1526-4602
DOI: 10.1021/bm701055k